Products for use in research and development & GMP

For process development and GMP manufacturing of biologicals such as viral vectors and vaccines. Removing all forms of DNA and RNA, DENARASE^® enhables a simpler, more efficient downstream process.

• DENARASE^® GMP-grade is manufactured under EU GMP conditions
• DENARASE^® R&D-grade is produced in conformity with the ISO 9001 standard, with less strict requirements regarding documentation, storage and distribution
• From a technical performance perspective, both quality grades are equal and the parameters on the specification are the same. This allows for a seamless transition from early R&D stage towards biopharmaceutical manufacturing under GMP.

Products for use in research and development & GMP 

DENARASE^® High Salt is designed to retain activity at elevated salt and different pH levels. It is specifically engineered for use in development and manufacturing processes, that benefit from salt additions. The salt-tolerant enzyme efficiently cleaves all forms of DNA and RNA across a broad range of process-relevant conditions, facilitating flexible and more efficient production of biologicals, such as viral vectors and vaccines. 

• DENARASE^® High Salt GMP-grade manufacturing complies with EU GMP standards. 
• DENARASE^® High Salt R&D-grade is produced under ISO 9001 standard. 
• Both quality grades of DENARASE^® High Salt are technically equivalent, enabling a seamless transition from early R&D stages to biopharmaceutical manufacturing under GMP. 

ELISA Kit for DENARASE^®, DENARASE^® High Salt and Benzonase*

For the quantitative analysis of residual Serratia marcescens endonucleases including DENARASE^® High Salt in process samples.

• The kit consists of a pre-coated micro test plate and all ready to use reagents. ​
• The capacity of 1 kit is 480 measurements ​
• Estimated Delivery time: 1-2 weeks (depending on region)​
• Net price excluding VAT and shipment costs

*Benzonase Nuclease is a registered trademark of Merck KGaA

For process development of biologicals such as viral vectors and vaccines. The enzyme cleaves all forms of DNA and RNA and enables a simpler, more efficient downstream process.

Purity: ≥ 99%​
Activity: > 250 U/µl​
Formulation: buffered aqueous glycerol solution
Storage Temperature: -20°C
Estimated Delivery time: 1-2 weeks (depending on region)

• Produced in conformity with ISO 9001 standard
• Manufacturing free of animal derived raw materials and antibiotics
• Depending on your application 10 – 60 U/ml is needed ​
• Net price excluding VAT and shipment costs

• Produced under EU GMP conditions
• Manufacturing free of animal derived raw materials and antibiotics
• Dedicated regulatory support for US-market approvals of pharmaceutical products via own US FDA Drug Master File
• Net price excluding VAT and shipment costs

Products for use in research and development 

Intended for use in process development of biologicals such as viral vectors and vaccines. The salt-tolerant enzyme cleaves all forms of DNA and RNA and enables a simpler, more efficient downstream process at salt concentrations above 150 mM. 

• Produced under ISO 9001 standard
• Manufactured without the use of antibiotics, Triton X-100 and raw materials of animal origin
• Depending on your application 10 – 100 U/ml is needed
• Net price excluding VAT and shipment costs 

GMP products for biopharmaceutical manufacturing  

Intended for use in GMP manufacturing of biologicals such as viral vectors and vaccines. The salt-tolerant enzyme cleaves all forms of DNA and RNA and enables a simpler, more efficient downstream process salt at concentrations above 150 mM. 

• Manufacturing of the GMP-grade DENARASE® High Salt complies with the same stringent regulations and standards as the wild-type GMP-grade DENARASE® products.  
• Produced under GMP conditions complying with EU GMP regulations 
• Manufactured without the use of antibiotics, Triton X-100 and raw materials of animal origin 
• Net price excluding VAT and shipment costs 

A powerful enzyme for DNA removal."