DENARASE^® High Salt - Enzyme Characteristics

Cofactor
Magnesium (Mg²⁺) is an essential cofactor and prerequisite for the activity of DENARASE^® High Salt. Requiring the presence of minimal magnesium levels for basal activity, DENARASE^® High Salt shows optimal activity at
5-25 mM Mg²⁺. However, excess of MgCl₂ will reduce DENARASE^® High Salt activity (see Fig. 2).

Stability and Storage Conditions
When stored properly (-20 °C ± 5 °C), the enzyme is stable for at least 6 months from the date of quality control release. The long-term stability of DENARASE^® High Salt is currently under investigation. 

Packaging Information
DENARASE^® High Salt is filled in non-pyrogenic, USP Class VI compliant vials. The product vials are shipped under qualified cooled conditions. The shipping temperature may differ from the recommended storage temperature without affecting product quality. All DENARASE^® High Salt products will be delivered by c-LEcta in a sealed secondary packaging with tamper-evident seals.

Salt & Magnesium Concentration

DENARASE^® High Salt has been designed to enable DNA clearance activity at higher, process relevant, salt conditions (see Fig. 1). The engineered enzyme exhibits activity from 0-500 mM monovalent cation concentrations.

pH & Temperature