How to compare the technical performance of 𝙎𝙚𝙧𝙧𝙖𝙩𝙞𝙖 𝙢𝙖𝙧𝙘𝙚𝙨𝙘𝙚𝙣𝙨 endonucleases such as DENARASE & Benzonase?

Endonucleases are widely used in the manufacturing of viral vectors for cell and gene therapies. BioPhorum recently highlighted an industry challenge: How to compare the technical performance of Serratia marcescens endonucleases such as Benzonase^®1 and DENARASE^®?
Read the article here: https://www.biophorum.com/an-industry-first-unifying-the-release-standards-for-cgt-ancillary-materials/ 

The comparability of endonucleases is essential to secure supply chains, including dual sourcing strategies. In this study the DENARASE^® activity release test developed by c-LEcta for its DENARASE^® product is used, to compare activities of DENARASE^® and Benzonase^®. By applying the DENARASE^® activity release assay test protocol to both enzymes, the correspondence of these results to the respective product's CoA values was evaluated.

Reach out to our DENARASE^® expert team if you are interested to discuss the data!

¹ Benzonase Nuclease is a registered trademark of Merck KGaA