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Webinar: Discover the benefits of higher salt concentrations in viral vector manufacturing

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Join Marc Struhalla (CEO) and Svenja Michalek (Product Manager Biopharma) as they introduce a novel engineered variant of the Serratia marcescens wild-type enzyme, which is more tolerant to higher salt concentrations and can streamline the viral vector manufacturing process. In addition, we will show data generated by a cell and gene therapy CDMO that compared DENARASE® High Salt with another commercially available salt-tolerant endonuclease (SAN HQ) in an AAV2 harvest.

DENARASE® toolkit - Enzymatic DNA Removal in Bioprocessing

  • High activity to all forms of DNA/RNA

  • High purity ≥99 %

  • Manufacturing free of animal derived materials and antibiotics

  • Triton-free

  • Endotoxin-free expression host

  • High activity and high purity 

  • One-for-all Serratia marcescens ELISA Kits

  • Comprehensive technical support by our team of experts

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DENARASE_GMP_R&D
DENARASE_High Salt_Group
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DENARASE®

  • Produced under GMP conditions

  • For use at 0-200 mM salt

DENARASE® High Salt

  • Engineered from DENARASE® for better salt and pH tolerance

  • For use at 0-500 mM salt

DENARASE® ELISA Kit

  • For the quantification of residual Serratia marcescens endonucleases including DENARASE® High Salt

  • Use of a monoclonal antibody enables unmatched accuracy & reproducibility

Order your DENARASE® toolkit now!

  • DENARASE® High Salt

    Products for use in research and development

    Intended for use in process development of biologicals such as viral vectors and vaccines. The salt-tolerant enzyme cleaves all forms of DNA and RNA and enables a simpler, more efficient downstream process salt concentrations above 200 mM.
     
    Purity: ≥ 99%​
    Activity: > 250 U/µl​
    Formulation:     buffered aqueous glycerol solution
    Storage Temperature:     -20°C
    Estimated Delivery time:     1-2 weeks (depending on region)
     
    • Produced under ISO 9001 standard
    • Manufactured without the use of antibiotics, Triton X-100 and raw materials of animal origin
    • Net price excluding VAT and shipment costs
    DENARASE_High Salt_Group

    Choose your size for DENARASE® High Salt:

    Back to the section
  • DENARASE®

    Products for use in research and development & GMP

    At lower to physiological salt conditions (0-200 mM) the standard DENARASE® exhibits unmatched performance and will continue to be the most economical solution.
     
    Purity: ≥ 99%​
    Activity: > 250 U/µl​
    Formulation:     buffered aqueous glycerol solution
    Storage Temperature:     -20°C
    Estimated Delivery time:     1-2 weeks (depending on region)

    • DENARASE® GMP-grade is manufactured under EU GMP conditions
    • DENARASE® R&D-grade is produced in conformity with the ISO 9001 standard.
    • From a technical performance perspective, both quality grades are equal.This allows for a seamless transition from early R&D stage towards biopharmaceutical manufacturing under GMP.
    DENARASE_GMP_R&D

    Choose your DENARASE® grade:

    Back to the section
  • DENARASE® ELISA Kit

    ELISA Kit for DENARASE®, DENARASE® High Salt and Benzonase®*

    For the quantitative analysis of residual Serratia marcescens endonucleases including DENARASE® High Salt in process samples.

    Save 20% on your first order with code ELISAKit_20

    • The kit consists of 5 precoated micro test plates and all ready to use reagents ​
    • The capacity of 1 kit is 480 measurements ​
    • Estimated Delivery time: 1-2 weeks (depending on region)​
    • net price excluding VAT and shipment costs

    *Benzonase Nuclease is a registered trademark of Merck KGaA

    Eric-Kemnitz_0855_01

    Back to the section
  • Free Sample

Products for use in research and development

Intended for use in process development of biologicals such as viral vectors and vaccines. The salt-tolerant enzyme cleaves all forms of DNA and RNA and enables a simpler, more efficient downstream process salt concentrations above 200 mM.
 
Purity: ≥ 99%​
Activity: > 250 U/µl​
Formulation: buffered aqueous glycerol solution
Storage Temperature: -20°C
Estimated Delivery time: 1-2 weeks (depending on region)
 
  • Produced under ISO 9001 standard
  • Manufactured without the use of antibiotics, Triton X-100 and raw materials of animal origin
  • Net price excluding VAT and shipment costs
DENARASE_High Salt_Group

Choose your size for DENARASE® High Salt:

Products for use in research and development & GMP

At lower to physiological salt conditions (0-200 mM) the standard DENARASE® exhibits unmatched performance and will continue to be the most economical solution.
 
Purity: ≥ 99%​
Activity: > 250 U/µl​
Formulation: buffered aqueous glycerol solution
Storage Temperature: -20°C
Estimated Delivery time: 1-2 weeks (depending on region)

  • DENARASE® GMP-grade is manufactured under EU GMP conditions
  • DENARASE® R&D-grade is produced in conformity with the ISO 9001 standard.
  • From a technical performance perspective, both quality grades are equal.This allows for a seamless transition from early R&D stage towards biopharmaceutical manufacturing under GMP.
DENARASE_GMP_R&D

Choose your DENARASE® grade:

ELISA Kit for DENARASE®, DENARASE® High Salt and Benzonase®*

For the quantitative analysis of residual Serratia marcescens endonucleases including DENARASE® High Salt in process samples.

Save 20% on your first order with code ELISAKit_20

  • The kit consists of 5 precoated micro test plates and all ready to use reagents ​
  • The capacity of 1 kit is 480 measurements ​
  • Estimated Delivery time: 1-2 weeks (depending on region)​
  • net price excluding VAT and shipment costs

*Benzonase Nuclease is a registered trademark of Merck KGaA

Eric-Kemnitz_0855_01

Get in touch with our DENARASE® expert team!

Vaishnavi Devarakonda

Vaishnavi Devarakonda
DENARASE® Sales

Need support? Contact me!
Melissa Rangel

Melissa Rangel
DENARASE® Sales

Need support? Contact me!

Cynthia Hofmann-Orsetti

Cynthia Hofmann-Orsetti
DENARASE® Sales

Need support? Contact me!